POLISITEMIA VERA PDF

Note reddish limbs and swelling. People with polycythemia vera can be asymptomatic. A classic symptom of polycythemia vera and the related myeloproliferative disease essential thrombocythemia is erythromelalgia. Erythromelalgia is caused by an increased platelet count or increased platelet "stickiness" aggregation , resulting in the formation of tiny blood clots in the vessels of the extremity; it responds rapidly to treatment with aspirin. A major thrombotic complication e.

Author:Tulabar Voodoogul
Country:Jordan
Language:English (Spanish)
Genre:Automotive
Published (Last):20 April 2010
Pages:318
PDF File Size:20.99 Mb
ePub File Size:15.69 Mb
ISBN:361-9-46333-422-3
Downloads:51931
Price:Free* [*Free Regsitration Required]
Uploader:Tuzahn



Note reddish limbs and swelling. People with polycythemia vera can be asymptomatic. A classic symptom of polycythemia vera and the related myeloproliferative disease essential thrombocythemia is erythromelalgia. Erythromelalgia is caused by an increased platelet count or increased platelet "stickiness" aggregation , resulting in the formation of tiny blood clots in the vessels of the extremity; it responds rapidly to treatment with aspirin.

A major thrombotic complication e. Headaches, lack of concentration and fatigue are common symptoms that occur in patients with polycythemia vera as well. Pathophysiology[ edit ] Polycythemia vera PCV , being a primary polycythemia , is caused by neoplastic proliferation and maturation of erythroid , megakaryocytic and granulocytic elements to produce what is referred to as panmyelosis. The diagnosis is often suspected on the basis of laboratory tests.

Common findings include an elevated hemoglobin level and hematocrit , reflecting the increased number of red blood cells; the platelet count or white blood cell count may also be increased. The erythrocyte sedimentation rate ESR is decreased due to an increase in zeta potential. Because polycythemia vera results from an essential increase in erythrocyte production, patients have normal blood oxygenation and a low erythropoietin EPO level.

In addition, the total blood volume sometimes increases to as much as twice normal. The entire vascular system can become markedly engorged with blood, and circulation times for blood throughout the body can increase up to twice the normal value. The increased numbers of erythrocytes can cause the viscosity of the blood to increase as much as five times normal.

Capillaries can become plugged by the very viscous blood, and the flow of blood through the vessels tends to be extremely sluggish. As a consequence of the above, people with untreated polycythemia vera are at a risk of various thrombotic events deep venous thrombosis , pulmonary embolism , heart attack and stroke , and have a substantial risk of Budd-Chiari syndrome hepatic vein thrombosis , [13] or myelofibrosis. The condition is considered chronic; no cure exists.

Symptomatic treatment see below can normalize the blood count and most patients can live a normal life for years. The disease appears more common in Jews of European extraction than in most non-Jewish populations. Some familial forms of polycythemia vera are noted, but the mode of inheritance is not clear. This mutation may be helpful in making a diagnosis or as a target for future therapy.

LUCY GREALY AUTOBIOGRAPHY OF A FACE PDF

Policitemia vera

It causes your bone marrow to make too many red blood cells. These excess cells thicken your blood, slowing its flow, which may cause serious problems, such as blood clots. Polycythemia vera is rare. It usually develops slowly, and you might have it for years without knowing. Often the condition is found during a blood test done for another reason. Without treatment, polycythemia vera can be life-threatening.

KURGUSAL SOZLUK PDF

Polisitemia Vera

.

Related Articles